Rivaroxaban and apixaban induce clotting factor Xa fibrinolytic activity
نویسندگان
چکیده
منابع مشابه
Measured by Activated Clotting Time and Factor Xa Inhibition
The effect of hypothermia on heparin anticoagulation was studied using (siliceous earth) activated clotting time (ACT) measured by the modified Hattersley technique and anti-factor Xa assay measured by the modified Teien technique during cardiopulmonary bypass (CPB). Seventeen adult patients with normal blood coagulation function undergoing their first time coronary artery bypass grafting surge...
متن کاملMeasurement of Anti-Factor Xa Activity in Patients on Apixaban for Non-Valvular Atrial Fibrillation.
BACKGROUND Chromogenic anti-factor Xa activity (AXA) assay is reported to be the most appropriate method to measure the pharmacodynamics of apixaban, but the distribution of AXA in non-valvular atrial fibrillation (NVAF) patients on apixaban therapy has not been fully elucidated. METHODSANDRESULTS Steady-state trough and peak AXA were measured in 124 NVAF patients taking apixaban. In 25 patie...
متن کاملRivaroxaban: an oral direct inhibitor of factor Xa.
PURPOSE The mechanism of action, pharmacodynamics, pharmacokinetics, efficacy in clinical trials, interactions, adverse effects and toxicity, and place in therapy of rivaroxaban are reviewed. SUMMARY Rivaroxaban, the first oral, direct factor Xa (FXa) inhibitor to reach Phase III trials, inhibits thrombin generation by both the intrinsic and the tissue factor pathways. It has shown predictabl...
متن کاملClotting and fibrinolytic changes after firefighting activities.
UNLABELLED Approximately 45%-50% of all duty-related deaths among firefighters are due to sudden cardiovascular events, and a disproportionate number of these fatalities occur after strenuous fire suppression activities. PURPOSE The objective of this study is to evaluate the effect of strenuous firefighting activities on platelets, coagulation, and fibrinolytic activity and to document the ex...
متن کاملMeasurement of rivaroxaban and apixaban in serum samples of patients
BACKGROUND The determination of rivaroxaban and apixaban from serum samples of patients may be beneficial in specific clinical situations when additional blood sampling for plasma and thus the determination of factor Xa activity is not feasible or results are not plausible. MATERIALS AND METHODS The primary aim of this study was to compare the concentrations of rivaroxaban and apixaban in ser...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2018
ISSN: 1538-7933
DOI: 10.1111/jth.14281